HETEROTRANSPLANTATIONS AND GENOMIC IN CANCER RESEARCH
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Abstract
We performed ,in 1975, the first heterotransplantation of invertebrate A.O in nude mouse, then a double heterotransplantation of human tumor and Axial organ next to this last one, always in nude mouse: The human tumor was rejected in 50% of observed cases.Some
years later, we found that A.O cells exerted an induced and spontaneous cytotoxicity against SP2 and MBL2 mouse tumoral cells.Recently, we discovered a sea star Igkappa gene with immune properties. This gene was inserted in a CMV(cytomegalovirus) and finally in a plasmid called « young » plasmid.
The induced« young » protein exerted a spontaneous cytotoxicity against osteosarcom cells (U2oS cells) against A-375 melanome cells and Hela cells
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